Sedusa is a recurring antagonist in the ianime adaptation Powerpuff Girls Z. She was voiced by Jennifer Hale in the original series and Rebecca Shoichet in the anime.When Ms. Bellum is away, Annie finds Ms. Bellum's lipstick. While trying it on outside her restaurant, she was struck by Black Z-Rays.
In her debut, "Sedusa", she was first seen making coffee and trying to impress her crush, Jason, but accidentally spills it on him. Blossom notices Annie's feelings for him which embarrasses her.
The next day, she once again tries to impress Jason as she goes in a makeup store. The store lady insists that she try a sample of lipstick, to which Annie refuses. However, despite Annie not wanting to, the lady puts a sample of lipstick on her lips. As the lady goes to get more samples, Annie transforms into Sedusa, who goes on a stealing spree, targeting clothes, makeup, and jewelry.
The Powerpuff Girls investigate Sedusa's crimes and find out where she will strike next. Heading for a store, Bubbles goes inside the mall as Blossom and Buttercup are on look out. Suddenly, they find Bubbles tied up and they go look for Sedusa. However; it is quickly revealed to be Sedusa in a form of Bubbles. She then tries to trick Bubbles out of the store (disguised as Buttercup) but fails as Bubbles figures it couldn't be Buttercup as she dislike cologne (or in that fact, dislikes girly stuff). Shortly, Blossom and Buttercup find Bubbles and confront her, who reveals herself. Sedusa tries to make a getaway but is soon knocked out by Buttercup's Piko Piko Hammer.
The girls take an unconscious Sedusa to the Professor's lab, and Professor removes the Black Z-Rays. They see her turn back to her originally form and recognize Annie.
The next day, Annie recovers and goes back to the shop, where The Powerpuff Girls and Ms. Bellum are relaxing. As Annie cleans up, Jason appears in the shop. Jason then admits his love for her as he holds her hands. Annie thanks Ms. Bellum for helping her, who appears confused of what she's talking about but doesn't question her.Annie is a sweet and quiet young girl and a friend of Blossom, Bubbles, and Buttercup. She appears to be a bit shy when near Jason, who she has a crush on. It seems that Annie dislikes her lack of appearance.